One of the biggest mysteries in physics today is the nature of dark matter. Direct detection of dark matter using low background underground detectors will allow us to probe the nature of dark matter and the new physics beyond the Standard Model. Our group has pioneered the development of liquid xenon detectors for the search of dark matter at deep underground labs. We increased the dark matter search sensitivity by more than three orders of magnitude in the last decade with the XENON10, XENON100 and XENON1T experiments at Gran Sasso Underground Laboratory (LNGS) in Italy and the PandaX-I and PandaX-II experiments at China Jinping Underground Laboratory (CJPL). Currently our group is actively involved in the XENON1T dark matter experiment, which is the world’s largest running dark matter direct detection experiment using 3.2 tons of pure liquid xenon.