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Progress in fundamental aspects of vascular flow and neurovascular control, functional imaging, and disease states of brain vasculature, such as stroke, all require a complete map of brain vasculature in relation to the underlying neurons and nonneuronal cells.
We use optical sectioning, including all optical histology, together with advanced morphometric methods to form a vectorized map of the location of all cortical vessels and cells. Past work has focused on tool development and the statistical relationship of cells and vessls in sub-millimeter-cubed regions. Ongoing work aims to reconstruct all vessels and cells in vibrissa primary sensory cortex, an approximately ten-millimeter-cubed region.
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